Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer

Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analy...

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Detalles Bibliográficos
Autores principales: Beniaminov, Artemy D., Puzanov, Grigory A., Krasnov, George S., Kaluzhny, Dmitry N., Kazubskaya, Tatiana P., Braga, Eleonora A., Kudryavtseva, Anna V., Melnikova, Nataliya V., Dmitriev, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962711/
https://www.ncbi.nlm.nih.gov/pubmed/29868117
http://dx.doi.org/10.3389/fgene.2018.00169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962711/
https://www.ncbi.nlm.nih.gov/pubmed/29868117
http://dx.doi.org/10.3389/fgene.2018.00169

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