PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma

Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. In addition to elevation of O(6)-methylguanine DNA methyltransferase (MGMT), down-regulation of three DNA repair pathways; canonical mismatch repair (MMR), Non...

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Detalles Bibliográficos
Autores principales: Sharpe, Martyn A., Raghavan, Sudhir, Baskin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963626/
https://www.ncbi.nlm.nih.gov/pubmed/29844863
http://dx.doi.org/10.18632/oncotarget.25246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963626/
https://www.ncbi.nlm.nih.gov/pubmed/29844863
http://dx.doi.org/10.18632/oncotarget.25246

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