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Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs

Purpose: Lifitegrast is approved in the United States for the treatment of dry eye disease (DED). We assessed lifitegrast's ocular distribution/pharmacokinetic profile in rabbits, and (14)C-lifitegrast mass balance/excretion in dogs. Methods: Female pigmented rabbits received a single topical o...

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Detalles Bibliográficos
Autores principales:	Chung, Jou-Ku, Spencer, Elizabeth, Hunt, Matthew, McCauley, Thomas, Welty, Devin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963635/ https://www.ncbi.nlm.nih.gov/pubmed/29267138 http://dx.doi.org/10.1089/jop.2017.0106

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