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mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms
Transgenic mouse models are indispensable tools to mimic human diseases and analyze the effectiveness of related new drugs. For a long time amyotrophic lateral sclerosis (ALS) research depended on only a few mouse models that exhibit a very strong and early phenotype, e.g. SOD1 mice, resulting in a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963763/ https://www.ncbi.nlm.nih.gov/pubmed/29787578 http://dx.doi.org/10.1371/journal.pone.0197674 |