Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs....

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Detalles Bibliográficos
Autores principales: Chakraborty, Mouli, Sellier, Chantal, Ney, Michel, Pascal, Villa, Charlet-Berguerand, Nicolas, Artero, Ruben, Llamusi, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963859/
https://www.ncbi.nlm.nih.gov/pubmed/29592894
http://dx.doi.org/10.1242/dmm.032557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963859/
https://www.ncbi.nlm.nih.gov/pubmed/29592894
http://dx.doi.org/10.1242/dmm.032557

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