Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine

N(4)‐Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine (Ro 09–1390), a prodrug of the cytostatic 5′‐deoxy‐5‐fluorouridine (5′‐DFUR), was synthesized with the aim of reducing of the dose‐limiting toxicity of 5′‐DFUR, which is diarrhea. In mice bearing Lewis lung carcinoma, 5′‐DFUR given po produced a subst...

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Detalles Bibliográficos
Autores principales: Ninomiya, Yasuyuki, Miwa, Masanori, Eda, Hiroyuki, Sahara, Hiroshi, Fujimoto, Kaori, Ishida, Masako, Umeda, Isao, Yokose, Kazuteru, Ishitsuka, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963899/
https://www.ncbi.nlm.nih.gov/pubmed/2139643
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02547.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963899/
https://www.ncbi.nlm.nih.gov/pubmed/2139643
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02547.x

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