Multivalency regulates activity in an intrinsically disordered transcription factor

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The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays,...

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Detalles Bibliográficos
Autores principales: Clark, Sarah, Myers, Janette B, King, Ashleigh, Fiala, Radovan, Novacek, Jiri, Pearce, Grant, Heierhorst, Jörg, Reichow, Steve L, Barbar, Elisar J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963919/
https://www.ncbi.nlm.nih.gov/pubmed/29714690
http://dx.doi.org/10.7554/eLife.36258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963919/
https://www.ncbi.nlm.nih.gov/pubmed/29714690
http://dx.doi.org/10.7554/eLife.36258

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