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Multivalency regulates activity in an intrinsically disordered transcription factor
The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays,...
Autores principales: | Clark, Sarah, Myers, Janette B, King, Ashleigh, Fiala, Radovan, Novacek, Jiri, Pearce, Grant, Heierhorst, Jörg, Reichow, Steve L, Barbar, Elisar J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963919/ https://www.ncbi.nlm.nih.gov/pubmed/29714690 http://dx.doi.org/10.7554/eLife.36258 |
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