Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic

Identifying targets of antibacterial compounds remains a challenging step in antibiotic development. We have developed a two-pronged functional genomics approach to predict mechanism of action that uses mutant fitness data from antibiotic-treated transposon libraries containing both upregulation and...

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Detalles Bibliográficos
Autores principales: Santiago, Marina, Lee, Wonsik, Fayad, Antoine Abou, Coe, Kathryn A., Rajagopal, Mithila, Do, Truc, Hennessen, Fabienne, Srisuknimit, Veerasak, Müller, Rolf, Meredith, Timothy C., Walker, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964011/
https://www.ncbi.nlm.nih.gov/pubmed/29662210
http://dx.doi.org/10.1038/s41589-018-0041-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964011/
https://www.ncbi.nlm.nih.gov/pubmed/29662210
http://dx.doi.org/10.1038/s41589-018-0041-4

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