Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells

Hirsutine extracted from Uncaria rhynchophylla has been shown to exhibit anti-cancer activity. However, the molecular mechanism by which hirsutine exhibits anti-lung cancer activity remains unclear. In the present study, we showed that hirsutine induces apoptosis in human lung cancer cells via loss...

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Detalles Bibliográficos
Autores principales: Zhang, Rong, Li, Guobing, Zhang, Qian, Tang, Qin, Huang, Jingbin, Hu, Changpeng, Liu, Yali, Wang, Qing, Liu, Wuyi, Gao, Ning, Zhou, Shiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964100/
https://www.ncbi.nlm.nih.gov/pubmed/29789524
http://dx.doi.org/10.1038/s41419-018-0641-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964100/
https://www.ncbi.nlm.nih.gov/pubmed/29789524
http://dx.doi.org/10.1038/s41419-018-0641-7

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