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Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells

Hirsutine extracted from Uncaria rhynchophylla has been shown to exhibit anti-cancer activity. However, the molecular mechanism by which hirsutine exhibits anti-lung cancer activity remains unclear. In the present study, we showed that hirsutine induces apoptosis in human lung cancer cells via loss...

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Detalles Bibliográficos
Autores principales:	Zhang, Rong, Li, Guobing, Zhang, Qian, Tang, Qin, Huang, Jingbin, Hu, Changpeng, Liu, Yali, Wang, Qing, Liu, Wuyi, Gao, Ning, Zhou, Shiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964100/ https://www.ncbi.nlm.nih.gov/pubmed/29789524 http://dx.doi.org/10.1038/s41419-018-0641-7

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