Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury

The mitochondrial calcium uniporter (MCU) mediates high-capacity mitochondrial calcium uptake that stimulates energy production. However, excessive MCU activity can cause ischemic heart injury. To examine if the MCU is also involved in hypoxic/ischemic (HI) brain injury, we have generated conditiona...

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Detalles Bibliográficos
Autores principales: Nichols, Matthew, Pavlov, Evgeny V., Robertson, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964108/
https://www.ncbi.nlm.nih.gov/pubmed/29789575
http://dx.doi.org/10.1038/s41419-018-0607-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964108/
https://www.ncbi.nlm.nih.gov/pubmed/29789575
http://dx.doi.org/10.1038/s41419-018-0607-9

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