Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular impact of ALS-causing mutations on neuronal development and disease, we analysed transcriptomes during in vitro differentiation of motor neurons (...

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Detalles Bibliográficos
Autores principales: Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964114/
https://www.ncbi.nlm.nih.gov/pubmed/29789581
http://dx.doi.org/10.1038/s41467-018-04373-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964114/
https://www.ncbi.nlm.nih.gov/pubmed/29789581
http://dx.doi.org/10.1038/s41467-018-04373-8

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