Cargando…

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular impact of ALS-causing mutations on neuronal development and disease, we analysed transcriptomes during in vitro differentiation of motor neurons (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964114/ https://www.ncbi.nlm.nih.gov/pubmed/29789581 http://dx.doi.org/10.1038/s41467-018-04373-8

Ejemplares similares

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis
por: Tyzack, Giulia E, et al.
Publicado: (2019)

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis
por: Tyzack, Giulia E, et al.
Publicado: (2021)

Automated and unbiased discrimination of ALS from control tissue at single cell resolution
por: Hagemann, Cathleen, et al.
Publicado: (2021)

Reactive astrocytes in ALS display diminished intron retention
por: Ziff, Oliver J, et al.
Publicado: (2021)

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS
por: Tyzack, Giulia E, et al.
Publicado: (2020)

The FUS about SFPQ in FTLD spectrum disorders
por: Patani, Rickie
Publicado: (2020)

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis
por: Petrić Howe, Marija, et al.
Publicado: (2022)

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
por: Soreq, Lilach, et al.
Publicado: (2017)

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis
por: Smethurst, Phillip, et al.
Publicado: (2020)

Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS
por: Taylor, Richard, et al.
Publicado: (2022)

Image‐based deep learning reveals the responses of human motor neurons to stress and VCP‐related ALS
por: Verzat, Colombine, et al.
Publicado: (2021)

Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders
por: Tyzack, Giulia, et al.
Publicado: (2016)

Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy
por: Malik, Bilal, et al.
Publicado: (2019)

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states
por: Ziff, Oliver J., et al.
Publicado: (2022)

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis
por: Taha, Doaa M, et al.
Publicado: (2022)

The translational potential of human induced pluripotent stem cells for clinical neurology: The translational potential of hiPSCs in neurology
por: Devine, Helen, et al.
Publicado: (2016)

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
por: Tyzack, Giulia E., et al.
Publicado: (2017)

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
por: Hall, Claire E., et al.
Publicado: (2017)

Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
por: Zhang, Dingxiao, et al.
Publicado: (2020)

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
por: Stagsted, Lotte Victoria Winther, et al.
Publicado: (2021)

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
por: Ziff, Oliver J., et al.
Publicado: (2023)

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons
por: Widagdo, Jocelyn, et al.
Publicado: (2022)

SFPQ promotes an oncogenic transcriptomic state in melanoma
por: Bi, O., et al.
Publicado: (2021)

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models
por: Ahmed, Mhoriam, et al.
Publicado: (2023)

Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells
por: Patani, Rickie
Publicado: (2016)

How Do You Identify m(6) A Methylation in Transcriptomes at High Resolution? A Comparison of Recent Datasets
por: Capitanchik, Charlotte, et al.
Publicado: (2020)

Ultraplex: A rapid, flexible, all-in-one fastq demultiplexer
por: Wilkins, Oscar G, et al.
Publicado: (2021)

clipplotr—a comparative visualization and analysis tool for CLIP data
por: Chakrabarti, Anob M., et al.
Publicado: (2023)

Intergenic RNA mainly derives from nascent transcripts of known genes
por: Agostini, Federico, et al.
Publicado: (2021)

The microglial component of amyotrophic lateral sclerosis
por: Clarke, Benjamin E, et al.
Publicado: (2020)

Acute depletion of METTL3 implicates N(6)-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
por: Wei, Guifeng, et al.
Publicado: (2021)

Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles
por: Clarke, Benjamin E, et al.
Publicado: (2020)

Towards resolution of the intron retention paradox in breast cancer
por: Shah, Jaynish S., et al.
Publicado: (2022)

RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis
por: Rafiee, Mahmoud-Reza, et al.
Publicado: (2023)

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides
por: Balendra, Rubika, et al.
Publicado: (2023)

A Non-Toxic Concentration of Telomerase Inhibitor BIBR1532 Fails to Reduce TERT Expression in a Feeder-Free Induced Pluripotent Stem Cell Model of Human Motor Neurogenesis
por: Pandya, Virenkumar A., et al.
Publicado: (2021)

The changing paradigm of intron retention: regulation, ramifications and recipes
por: Monteuuis, Geoffray, et al.
Publicado: (2019)

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability
por: Cosker, Katharina E, et al.
Publicado: (2016)

Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ
por: Huang, Jie, et al.
Publicado: (2020)

The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity
por: Brunet, Marie A, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gikvg28lb507k0j93eav07om2j