YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer

Aberrant activation of Wnt/β-catenin signalling is critical in the progression of human cancers, especially colorectal cancer (CRC). Therefore, inhibition of Wnt/β-catenin signalling is a significant potential target for CRC therapy. Here, we identified for the first time that Physalin F (PF), a ste...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Zhu, Dongrong, Zhang, Hao, Han, Chao, Xue, Guimin, Zhu, Tianyu, Luo, Jianguang, Kong, Lingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964149/
https://www.ncbi.nlm.nih.gov/pubmed/29789528
http://dx.doi.org/10.1038/s41419-018-0645-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964149/
https://www.ncbi.nlm.nih.gov/pubmed/29789528
http://dx.doi.org/10.1038/s41419-018-0645-3

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