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YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer

Aberrant activation of Wnt/β-catenin signalling is critical in the progression of human cancers, especially colorectal cancer (CRC). Therefore, inhibition of Wnt/β-catenin signalling is a significant potential target for CRC therapy. Here, we identified for the first time that Physalin F (PF), a ste...

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Detalles Bibliográficos
Autores principales:	Chen, Chen, Zhu, Dongrong, Zhang, Hao, Han, Chao, Xue, Guimin, Zhu, Tianyu, Luo, Jianguang, Kong, Lingyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964149/ https://www.ncbi.nlm.nih.gov/pubmed/29789528 http://dx.doi.org/10.1038/s41419-018-0645-3

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