Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats

Hyperandrogenism and hyperinsulinemia are main clinical endocrine features of PCOS. Exercise can adjust the androgen level, as well as increase the sensitivity of insulin by activating PI3K-Akt insulin signaling pathways. 5αR1 has certain effects on insulin resistance and can synthesize dihydrotesto...

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Detalles Bibliográficos
Autores principales: Wu, Chuyan, Jiang, Feng, Wei, Ke, Jiang, Zhongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964186/
https://www.ncbi.nlm.nih.gov/pubmed/29789599
http://dx.doi.org/10.1038/s41598-018-26210-0