Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets

Poly (ADP-ribose)ylation is a dynamic protein modification that regulates multiple cellular processes. Here, we describe a system for identifying and characterizing PARylation events that exploits the ability of a PBZ (PAR-binding zinc finger) protein domain to bind PAR with high-affinity. By linkin...

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Detalles Bibliográficos
Autores principales: Krastev, Dragomir B., Pettitt, Stephen J., Campbell, James, Song, Feifei, Tanos, Barbara E., Stoynov, Stoyno S., Ashworth, Alan, Lord, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964205/
https://www.ncbi.nlm.nih.gov/pubmed/29789535
http://dx.doi.org/10.1038/s41467-018-04466-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964205/
https://www.ncbi.nlm.nih.gov/pubmed/29789535
http://dx.doi.org/10.1038/s41467-018-04466-4

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