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Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
Poly (ADP-ribose)ylation is a dynamic protein modification that regulates multiple cellular processes. Here, we describe a system for identifying and characterizing PARylation events that exploits the ability of a PBZ (PAR-binding zinc finger) protein domain to bind PAR with high-affinity. By linkin...
Autores principales: | Krastev, Dragomir B., Pettitt, Stephen J., Campbell, James, Song, Feifei, Tanos, Barbara E., Stoynov, Stoyno S., Ashworth, Alan, Lord, Christopher J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964205/ https://www.ncbi.nlm.nih.gov/pubmed/29789535 http://dx.doi.org/10.1038/s41467-018-04466-4 |
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