Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells

Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogenic disomic and trisomic pluripotent cells, and observed tha...

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Detalles Bibliográficos
Autores principales: MacLean, Glenn A., McEldoon, Jennifer, Huang, Jialiang, Allred, Jeremy, Canver, Matthew C., Orkin, Stuart. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964225/
https://www.ncbi.nlm.nih.gov/pubmed/29789608
http://dx.doi.org/10.1038/s41598-018-26123-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964225/
https://www.ncbi.nlm.nih.gov/pubmed/29789608
http://dx.doi.org/10.1038/s41598-018-26123-y

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