The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival

Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH(2)-terminus in patients with Huntington’s disease. While numerous binding partners have been identified to NH(2)-terminal Htt, fewer proteins are known to interact with C-terminal domains of Htt. He...

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Detalles Bibliográficos
Autores principales: McClory, Hollis, Wang, Xiaolong, Sapp, Ellen, Gatune, Leah W., Iuliano, Maria, Wu, Chiu-Yi, Nathwani, Gina, Kegel-Gleason, Kimberly B., DiFiglia, Marian, Li, Xueyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964228/
https://www.ncbi.nlm.nih.gov/pubmed/29789657
http://dx.doi.org/10.1038/s41598-018-26255-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964228/
https://www.ncbi.nlm.nih.gov/pubmed/29789657
http://dx.doi.org/10.1038/s41598-018-26255-1

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