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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result of impaired phagocytosis of synapses by microgl...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964317/ https://www.ncbi.nlm.nih.gov/pubmed/29581545 http://dx.doi.org/10.1038/s41467-018-03566-5 |