Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity

Inactivation of sterol Δ(5,6)-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs. However, loss of Erg3p activity is also associated with deficiencies in stress tolerance, invasive hyphal growth,...

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Detalles Bibliográficos
Autores principales: Luna-Tapia, Arturo, Willems, Hubertine M. E., Parker, Josie E., Tournu, Hélène, Barker, Katherine S., Nishimoto, Andrew T., Rogers, P. David, Kelly, Steven L., Peters, Brian M., Palmer, Glen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964354/
https://www.ncbi.nlm.nih.gov/pubmed/29789366
http://dx.doi.org/10.1128/mBio.00225-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964354/
https://www.ncbi.nlm.nih.gov/pubmed/29789366
http://dx.doi.org/10.1128/mBio.00225-18

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