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Senescence drives non-cell autonomous tumorigenesis in the pituitary gland
Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964449/ https://www.ncbi.nlm.nih.gov/pubmed/29876518 http://dx.doi.org/10.1080/23723556.2018.1435180 |
| _version_ | 1783325181799825408 |
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| author | Gonzalez-Meljem, Jose Mario Martinez-Barbera, Juan Pedro |
| author_facet | Gonzalez-Meljem, Jose Mario Martinez-Barbera, Juan Pedro |
| author_sort | Gonzalez-Meljem, Jose Mario |
| collection | PubMed |
| description | Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in the widely unexplored phenomenon of paracrine tumorigenesis. |
| format | Online Article Text |
| id | pubmed-5964449 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59644492018-06-04 Senescence drives non-cell autonomous tumorigenesis in the pituitary gland Gonzalez-Meljem, Jose Mario Martinez-Barbera, Juan Pedro Mol Cell Oncol Author's Views Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in the widely unexplored phenomenon of paracrine tumorigenesis. Taylor & Francis 2018-02-13 /pmc/articles/PMC5964449/ /pubmed/29876518 http://dx.doi.org/10.1080/23723556.2018.1435180 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| spellingShingle | Author's Views Gonzalez-Meljem, Jose Mario Martinez-Barbera, Juan Pedro Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title_full | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title_fullStr | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title_full_unstemmed | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title_short | Senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| title_sort | senescence drives non-cell autonomous tumorigenesis in the pituitary gland |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964449/ https://www.ncbi.nlm.nih.gov/pubmed/29876518 http://dx.doi.org/10.1080/23723556.2018.1435180 |
| work_keys_str_mv | AT gonzalezmeljemjosemario senescencedrivesnoncellautonomoustumorigenesisinthepituitarygland AT martinezbarberajuanpedro senescencedrivesnoncellautonomoustumorigenesisinthepituitarygland |