Cargando…
The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis
Toxoplasma gondii is an obligate intracellular protozoan parasite of the phylum Apicomplexa, and toxoplasmosis is an important disease of both humans and economically important animals. With a limited array of drugs available there is a need to identify new therapeutic compounds. Aureobasidin A (AbA...
Autores principales: | ALQAISI, A. Q. I., MBEKEANI, A. J., LLORENS, M. BASSAS, ELHAMMER, A. P., DENNY, P. W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964465/ https://www.ncbi.nlm.nih.gov/pubmed/28486997 http://dx.doi.org/10.1017/S0031182017000506 |
Ejemplares similares
-
The antifungal Aureobasidin A and an analogue are active against the
protozoan parasite Toxoplasma gondii but do not inhibit
sphingolipid biosynthesis – Corrigendum
por: ALQAISI, A. Q. I., et al.
Publicado: (2018) -
Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis
por: MINA, JOHN G. M., et al.
Publicado: (2018) -
Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii
por: Pratt, Steven, et al.
Publicado: (2013) -
Impaired biosynthesis of ergosterol confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in a PDR16-dependent manner
por: Fukuda, Shizuka, et al.
Publicado: (2023) -
Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites
por: Mina, John G., et al.
Publicado: (2017)