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Fundamental deficiencies in the megatrial methodology

The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologically and prognostically heterogeneous subjects, and protocols typically fail to exclude sig...

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Detalles Bibliográficos
Autor principal: Charlton, Bruce G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59645/
https://www.ncbi.nlm.nih.gov/pubmed/11806765
http://dx.doi.org/10.1186/cvm-2-1-002