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Fundamental deficiencies in the megatrial methodology
The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologically and prognostically heterogeneous subjects, and protocols typically fail to exclude sig...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59645/ https://www.ncbi.nlm.nih.gov/pubmed/11806765 http://dx.doi.org/10.1186/cvm-2-1-002 |