Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide

Positron emission tomography (PET) imaging using [(11)C]metoclopramide, a P-glycoprotein (P-gp) substrate, was used to investigate the contribution of transport processes to metoclopramide liver clearance. The liver kinetics obtained after injection of [(11)C]metoclopramide were measured using PET i...

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Detalles Bibliográficos
Autores principales: Caillé, Fabien, Goutal, Sébastien, Marie, Solène, Auvity, Sylvain, Cisternino, Salvatore, Kuhnast, Bertrand, Pottier, Géraldine, Tournier, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964550/
https://www.ncbi.nlm.nih.gov/pubmed/29853808
http://dx.doi.org/10.1155/2018/7310146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964550/
https://www.ncbi.nlm.nih.gov/pubmed/29853808
http://dx.doi.org/10.1155/2018/7310146

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