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Improving the analysis of composite endpoints in rare disease trials
BACKGROUND: Composite endpoints are recommended in rare diseases to increase power and/or to sufficiently capture complexity. Often, they are in the form of responder indices which contain a mixture of continuous and binary components. Analyses of these outcomes typically treat them as binary, thus...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964664/ https://www.ncbi.nlm.nih.gov/pubmed/29788976 http://dx.doi.org/10.1186/s13023-018-0819-1 |