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Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model

BACKGROUND: It is known that dexmedetomidine can reduce opioid requirements and that there is a synergistic effect when dexmedetomidine and morphine (a full mu opioid receptor agonist) are administered together. However, it was unclear whether a synergistic or additive effect would be observed when...

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Detalles Bibliográficos
Autores principales: Huang, Ya-Qin, Guo, Shao-Hui, Liu, Renyu, Zhu, Sheng-Mei, Sun, Jian-Liang, Yao, Yong-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966251/
https://www.ncbi.nlm.nih.gov/pubmed/29849948
http://dx.doi.org/10.18632/oncotarget.25304