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Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model

BACKGROUND: It is known that dexmedetomidine can reduce opioid requirements and that there is a synergistic effect when dexmedetomidine and morphine (a full mu opioid receptor agonist) are administered together. However, it was unclear whether a synergistic or additive effect would be observed when...

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Autores principales: Huang, Ya-Qin, Guo, Shao-Hui, Liu, Renyu, Zhu, Sheng-Mei, Sun, Jian-Liang, Yao, Yong-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966251/
https://www.ncbi.nlm.nih.gov/pubmed/29849948
http://dx.doi.org/10.18632/oncotarget.25304
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author Huang, Ya-Qin
Guo, Shao-Hui
Liu, Renyu
Zhu, Sheng-Mei
Sun, Jian-Liang
Yao, Yong-Xing
author_facet Huang, Ya-Qin
Guo, Shao-Hui
Liu, Renyu
Zhu, Sheng-Mei
Sun, Jian-Liang
Yao, Yong-Xing
author_sort Huang, Ya-Qin
collection PubMed
description BACKGROUND: It is known that dexmedetomidine can reduce opioid requirements and that there is a synergistic effect when dexmedetomidine and morphine (a full mu opioid receptor agonist) are administered together. However, it was unclear whether a synergistic or additive effect would be observed when dexmedetomidine was co-administered with a partial mu opioid receptor agonist. The present study was designed to elucidate such effects by intrathecally co-administering dexmedetomidine and dezocine, a partial mu receptor agonist, in a mouse pain model. METHODS: C57 mice (N = 165) were randomly divided into 19 groups. The tail flick test was adopted to measure the antinociceptive effects of the tested agents. The mice were divided into saline and drug groups to investigate the dose-dependent analgesic effects. Each drug was administered at fixed doses alone and in combination with one of three doses of a second drug. RESULTS: Dezocine (0.3125 - 1.25 μg) and dexmedetomidine (0.04 - 1 μg) both enhanced the tail withdrawal latency in dose-dependent fashions. Dexmedetomidine (0.04 - 1 μg) enhanced the analgesic effect of dezocine. Dezocine (0.3125 - 1.25 μg) enhanced the analgesic effect of dexmedetomidine. Compared with the individual drug effects, the combined effects of dezocine (0.625 μg) and dexmedetomidine (0.04 μg) were more potent 15 - 60 min after injection, but they remained similar to the sum of the effects of the two individual drugs. CONCLUSIONS: Dexmedetomidine and dezocine produce an additive analgesic effect on acute nociception when administered simultaneously.
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spelling pubmed-59662512018-05-30 Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model Huang, Ya-Qin Guo, Shao-Hui Liu, Renyu Zhu, Sheng-Mei Sun, Jian-Liang Yao, Yong-Xing Oncotarget Research Paper BACKGROUND: It is known that dexmedetomidine can reduce opioid requirements and that there is a synergistic effect when dexmedetomidine and morphine (a full mu opioid receptor agonist) are administered together. However, it was unclear whether a synergistic or additive effect would be observed when dexmedetomidine was co-administered with a partial mu opioid receptor agonist. The present study was designed to elucidate such effects by intrathecally co-administering dexmedetomidine and dezocine, a partial mu receptor agonist, in a mouse pain model. METHODS: C57 mice (N = 165) were randomly divided into 19 groups. The tail flick test was adopted to measure the antinociceptive effects of the tested agents. The mice were divided into saline and drug groups to investigate the dose-dependent analgesic effects. Each drug was administered at fixed doses alone and in combination with one of three doses of a second drug. RESULTS: Dezocine (0.3125 - 1.25 μg) and dexmedetomidine (0.04 - 1 μg) both enhanced the tail withdrawal latency in dose-dependent fashions. Dexmedetomidine (0.04 - 1 μg) enhanced the analgesic effect of dezocine. Dezocine (0.3125 - 1.25 μg) enhanced the analgesic effect of dexmedetomidine. Compared with the individual drug effects, the combined effects of dezocine (0.625 μg) and dexmedetomidine (0.04 μg) were more potent 15 - 60 min after injection, but they remained similar to the sum of the effects of the two individual drugs. CONCLUSIONS: Dexmedetomidine and dezocine produce an additive analgesic effect on acute nociception when administered simultaneously. Impact Journals LLC 2018-05-11 /pmc/articles/PMC5966251/ /pubmed/29849948 http://dx.doi.org/10.18632/oncotarget.25304 Text en Copyright: © 2018 Huang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Huang, Ya-Qin
Guo, Shao-Hui
Liu, Renyu
Zhu, Sheng-Mei
Sun, Jian-Liang
Yao, Yong-Xing
Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title_full Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title_fullStr Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title_full_unstemmed Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title_short Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
title_sort additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966251/
https://www.ncbi.nlm.nih.gov/pubmed/29849948
http://dx.doi.org/10.18632/oncotarget.25304
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