Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

BACKGROUND: Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date. AIM O...

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Detalles Bibliográficos
Autores principales: Ahmad, Niyaz, Ahmad, Rizwan, Alam, Md Aftab, Ahmad, Farhan Jalees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966352/
https://www.ncbi.nlm.nih.gov/pubmed/29796830
http://dx.doi.org/10.1186/s13065-018-0434-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966352/
https://www.ncbi.nlm.nih.gov/pubmed/29796830
http://dx.doi.org/10.1186/s13065-018-0434-1

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