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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles
BACKGROUND: Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date. AIM O...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966352/ https://www.ncbi.nlm.nih.gov/pubmed/29796830 http://dx.doi.org/10.1186/s13065-018-0434-1 |