Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs) are f...

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Detalles Bibliográficos
Autores principales: Bolin, Sara, Borgenvik, Anna, Persson, Camilla U., Sundström, Anders, Qi, Jun, Bradner, James E., Weiss, William A., Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966365/
https://www.ncbi.nlm.nih.gov/pubmed/29511348
http://dx.doi.org/10.1038/s41388-018-0135-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966365/
https://www.ncbi.nlm.nih.gov/pubmed/29511348
http://dx.doi.org/10.1038/s41388-018-0135-1

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