C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Numerous small molecules (termed inducers), many of which are electrophiles, upregulate cytoprotective responses and inhibit pro-inflammatory pathways by activating nuclear factor-erythroid 2 p45-related factor 2 (NRF2). Key to NRF2 activation is the ability to chemically modifying critical sensor c...

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Detalles Bibliográficos
Autores principales: Dayalan Naidu, Sharadha, Muramatsu, Aki, Saito, Ryota, Asami, Soichiro, Honda, Tadashi, Hosoya, Tomonori, Itoh, Ken, Yamamoto, Masayuki, Suzuki, Takafumi, Dinkova-Kostova, Albena T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966396/
https://www.ncbi.nlm.nih.gov/pubmed/29795117
http://dx.doi.org/10.1038/s41598-018-26269-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966396/
https://www.ncbi.nlm.nih.gov/pubmed/29795117
http://dx.doi.org/10.1038/s41598-018-26269-9

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