Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility

Female gametes are stored in the ovary in structures called primordial follicles, the supply of which is non-renewable. It is well established that DNA-damaging cancer treatments can deplete the ovarian reserve of primordial follicles, causing premature ovarian failure and infertility. The precise m...

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Detalles Bibliográficos
Autores principales: Nguyen, Quynh-Nhu, Zerafa, Nadeen, Liew, Seng H., Morgan, F. Hamish, Strasser, Andreas, Scott, Clare L., Findlay, Jock K., Hickey, Martha, Hutt, Karla J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966424/
https://www.ncbi.nlm.nih.gov/pubmed/29795269
http://dx.doi.org/10.1038/s41419-018-0633-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966424/
https://www.ncbi.nlm.nih.gov/pubmed/29795269
http://dx.doi.org/10.1038/s41419-018-0633-7

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