Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model

Poly-ADP-ribose polymerases (PARPs) are involved in the regulation of important cellular processes, such as DNA repair, aging and apoptosis, among others. They have been considered as promising therapeutic targets, since human cancer cells carrying BRCA1 and BRCA2 mutations are highly sensitive to h...

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Detalles Bibliográficos
Autores principales: García-Saura, Antonio Ginés, Zapata-Pérez, Rubén, Hidalgo, José Francisco, Sánchez-Ferrer, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966428/
https://www.ncbi.nlm.nih.gov/pubmed/29795234
http://dx.doi.org/10.1038/s41598-018-26450-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966428/
https://www.ncbi.nlm.nih.gov/pubmed/29795234
http://dx.doi.org/10.1038/s41598-018-26450-0

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