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Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation

Human APOBEC3G (hA3G) is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. The virally encoded protein Vif binds to hA3G and induces its degradation, thereby counteracting the antiviral activity of hA3G. Vif-mediated hA3G degradation clearly represents a potentia...

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Detalles Bibliográficos
Autores principales: Ma, Ling, Zhang, Zhixin, Liu, Zhenlong, Pan, Qinghua, Wang, Jing, Li, Xiaoyu, Guo, Fei, Liang, Chen, Hu, Laixing, Zhou, Jinming, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966509/
https://www.ncbi.nlm.nih.gov/pubmed/29795228
http://dx.doi.org/10.1038/s41598-018-26318-3