STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome

BACKGROUND: Hyper-IgE syndrome (HIES) caused by loss-of-function (LOF) mutations in STAT3 gene (STAT3 LOF HIES) is associated with dental and facial abnormalities in addition to immunological defects. The role of STAT3 in the pathogenesis of the dental/facial features is, however, poorly elucidated....

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Detalles Bibliográficos
Autores principales: Goel, Shubham, Sahu, Smrity, Minz, Ranjana W., Singh, Surjit, Suri, Deepti, Oh, Young M., Rawat, Amit, Sehgal, Shobha, Saikia, Biman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966547/
https://www.ncbi.nlm.nih.gov/pubmed/29868029
http://dx.doi.org/10.3389/fimmu.2018.01080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966547/
https://www.ncbi.nlm.nih.gov/pubmed/29868029
http://dx.doi.org/10.3389/fimmu.2018.01080

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