Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats

Protease-activated receptor 4 (PAR4) is implicated in the inhibition of visceral hyperalgesia. In the present study, the effects of PAR4 activation on visceral hypersensitivity and expression of inflammatory mediators, including interleukin-1β (IL-1β), P2RX7 purinergic receptor (P2X7), inducible nit...

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Detalles Bibliográficos
Autores principales: Hao, Yanli, Niu, Hao, An, Shuhong, Wang, Ming, Wang, Zhaojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966670/
https://www.ncbi.nlm.nih.gov/pubmed/29854833
http://dx.doi.org/10.1155/2018/3256908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966670/
https://www.ncbi.nlm.nih.gov/pubmed/29854833
http://dx.doi.org/10.1155/2018/3256908

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