RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development

Retinoblastoma is rare tumor of the retina caused by the homozygous loss of the Retinoblastoma 1 tumor suppressor gene (RB1). Loss of the RB1 protein, pRB, results in de-regulated activity of the E2F transcription factors, chromatin changes and developmental defects leading to tumor development. Ext...

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Detalles Bibliográficos
Autores principales: Elchuri, Sailaja V., Rajasekaran, Swetha, Miles, Wayne O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966869/
https://www.ncbi.nlm.nih.gov/pubmed/29868118
http://dx.doi.org/10.3389/fgene.2018.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966869/
https://www.ncbi.nlm.nih.gov/pubmed/29868118
http://dx.doi.org/10.3389/fgene.2018.00170

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