MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

MicroRNAs (miRs) contribute to biological robustness by buffering cellular processes from external perturbations. Here we report an unexpected link between DNA damage response and angiogenic signaling that is buffered by a miR. We demonstrate that genotoxic stress-induced miR-494 inhibits the DNA re...

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Detalles Bibliográficos
Autores principales: Espinosa-Diez, Cristina, Wilson, RaeAnna, Chatterjee, Namita, Hudson, Clayton, Ruhl, Rebecca, Hipfinger, Christina, Helms, Erin, Khan, Omar F., Anderson, Daniel G., Anand, Sudarshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967305/
https://www.ncbi.nlm.nih.gov/pubmed/29795397
http://dx.doi.org/10.1038/s41419-018-0690-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967305/
https://www.ncbi.nlm.nih.gov/pubmed/29795397
http://dx.doi.org/10.1038/s41419-018-0690-y

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