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Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network

Genetic components susceptible to complex disease such as schizophrenia include a wide spectrum of variants, including common variants (CVs) and de novo mutations (DNMs). Although CVs and DNMs differ by origin, it remains elusive whether and how they interact at the gene, pathway, and network levels...

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Detalles Bibliográficos
Autores principales: Jia, Peilin, Chen, Xiangning, Fanous, Ayman H., Zhao, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967316/
https://www.ncbi.nlm.nih.gov/pubmed/29799522
http://dx.doi.org/10.1038/s41398-018-0154-2