An anti-EGFR × cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations

Antibody-drug conjugates (ADCs) can selectively deliver cytotoxic agents to tumor cells and are frequently more potent than naked antibodies. However, optimization of the conjugation process between antibodies and cytotoxic agents and characterization of ADCs are laborious and time-consuming process...

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Detalles Bibliográficos
Autores principales: Jin, Junyeong, Park, Gunwoo, Park, Jong Bae, Kim, Soohyun, Kim, Hyori, Chung, Junho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967348/
https://www.ncbi.nlm.nih.gov/pubmed/29795377
http://dx.doi.org/10.1038/s12276-018-0096-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967348/
https://www.ncbi.nlm.nih.gov/pubmed/29795377
http://dx.doi.org/10.1038/s12276-018-0096-z

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