Network Analysis of Protein Adaptation: Modeling the Functional Impact of Multiple Mutations

The evolution of new biochemical activities frequently involves complex dependencies between mutations and rapid evolutionary radiation. Mutation co-occurrence and covariation have previously been used to identify compensating mutations that are the result of physical contacts and preserve protein f...

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Detalles Bibliográficos
Autores principales: Beleva Guthrie, Violeta, Masica, David L, Fraser, Andrew, Federico, Joseph, Fan, Yunfan, Camps, Manel, Karchin, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967520/
https://www.ncbi.nlm.nih.gov/pubmed/29522102
http://dx.doi.org/10.1093/molbev/msy036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967520/
https://www.ncbi.nlm.nih.gov/pubmed/29522102
http://dx.doi.org/10.1093/molbev/msy036

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