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Network Analysis of Protein Adaptation: Modeling the Functional Impact of Multiple Mutations
The evolution of new biochemical activities frequently involves complex dependencies between mutations and rapid evolutionary radiation. Mutation co-occurrence and covariation have previously been used to identify compensating mutations that are the result of physical contacts and preserve protein f...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967520/ https://www.ncbi.nlm.nih.gov/pubmed/29522102 http://dx.doi.org/10.1093/molbev/msy036 |