The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

O-linked β-N-acetyl-(D)-glucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an essential post-translational modification that is abundant in the brain. Recently, OGT mutations have been associated with intellectual disability, although it is not understood how they affect OGT...

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Detalles Bibliográficos
Autores principales: Gundogdu, Mehmet, Llabrés, Salomé, Gorelik, Andrii, Ferenbach, Andrew T., Zachariae, Ulrich, van Aalten, Daan M.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967971/
https://www.ncbi.nlm.nih.gov/pubmed/29606577
http://dx.doi.org/10.1016/j.chembiol.2018.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967971/
https://www.ncbi.nlm.nih.gov/pubmed/29606577
http://dx.doi.org/10.1016/j.chembiol.2018.03.004

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