Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement

BACKGROUND: The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of FHIT suppresses tumor formation via induction of apoptosis. Fhit protein, a diadenosine polyphosphate hydrolase, does not require hydr...

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Detalles Bibliográficos
Autores principales: Varnum, James M, Baraniak, Janina, Kaczmarek, Renata, Stec, Wojciech J, Brenner, Charles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59680/
https://www.ncbi.nlm.nih.gov/pubmed/11701096
http://dx.doi.org/10.1186/1472-6769-1-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59680/
https://www.ncbi.nlm.nih.gov/pubmed/11701096
http://dx.doi.org/10.1186/1472-6769-1-3

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