Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives

Phenyl vinyl sulfone (PVS) and phenyl vinyl sulfonate (PVSN) inactivate protein tyrosine phosphatases (PTPs) by mimicking the phosphotyrosine structure and providing a Michael addition acceptor for the active-site cysteine residue of PTPs, thus forming covalent adducts between PVS (or PVSN) and PTPs...

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Detalles Bibliográficos
Autores principales: Yu, Cheng-Han, Chou, Chi-Chi, Lee, Der-Yen, Khoo, Kay-Hooi, Chang, Geen-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968187/
https://www.ncbi.nlm.nih.gov/pubmed/29540535
http://dx.doi.org/10.1042/BSR20171717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968187/
https://www.ncbi.nlm.nih.gov/pubmed/29540535
http://dx.doi.org/10.1042/BSR20171717

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