mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition

Unc-51 Like Kinase 1 (ULK1) is a critical regulator of the biogenesis of autophagosomes, the central component of the catabolic macroautophagy pathway. Regulation of ULK1 activity is dependent upon several phosphorylation events acting to repress or activate the enzymatic function of this protein. P...

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Detalles Bibliográficos
Autores principales: Manzoni, Claudia, Mamais, Adamantios, Dihanich, Sybille, Soutar, Marc P.M., Plun-Favreau, Helene, Bandopadhyay, Rina, Abeti, Rosella, Giunti, Paola, Hardy, John, R. Cookson, Mark, Tooze, Sharon A., Lewis, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968188/
https://www.ncbi.nlm.nih.gov/pubmed/29563162
http://dx.doi.org/10.1042/BSR20171669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968188/
https://www.ncbi.nlm.nih.gov/pubmed/29563162
http://dx.doi.org/10.1042/BSR20171669

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